Because of its weak MAO-inhibitory properties, the manufacturers of
linezolid caution its use with drugs such as phenylpropanolamine and pseudoephedrine unless there are facilities available for close observation of the patient and monitoring of blood pressure. However, the evidence available suggests that blood pressure rises are only very moderate and certainly unlikely to be of the hypertensive crisis proportions seen with the antidepressant
MAOIs.
If
linezolid and drugs such as these are prescribed patients should be monitored for
any rise in blood pressure. Patients should be warned about cough and cold remedies containing these and related drugs.