Classifications: lincosamide antibiotic; Therapeutic:antibiotic
Pregnancy Category: B
300 mg injection
Derived from Streptomyces lincolnensis and binds to the 50 S ribosomal subunits of the bacteria and inhibits protein synthesis, eventually resulting in inhibition
of bacterial cell growth or bacterial death. Antibacterial activity primarily results from inhibition of peptide bond formation.
Bacteriostatic or bactericidal depending on concentration used and sensitivity of organism. Effective against most of the
common gram-positive pathogens, particularly streptococci, pneumococci, and staphylococci. Also effective against many anaerobic
Reserved for treatment of serious infections caused by susceptible bacteria in penicillin-allergic patients or patients
for whom penicillin is inappropriate.
Previous hypersensitivity to lincomycin and clindamycin; impaired liver function, known monilial infections (unless treated
concurrently); use in newborns, lactation.
Impaired kidney function; history of GI disease, particularly colitis; history of liver, endocrine, or metabolic diseases;
history of asthma, hay fever, eczema, drug or other allergies; older adult patients, pregnancy (category B).
Route & Dosage
Adult: IM 600 mg q1224 h IV 600 mg1 g q812h (max: 8 g/d)
Child: IM 10 mg/kg q1224h IV 1020 mg/kg/d q812h
- Give injection deep into large muscle mass; inject slowly to minimize pain. Rotate injection sites.
PREPARE: Intermittent: Dilute each 1 g of lincomycin in at least 100 mL of D5W, NS, or other compatible solution.
ADMINISTER: Intermittent: Give at a rate ≤1 g/h.
INCOMPATIBILITIES Solution/additive: Carbenicillin, kanamycin, methicillin, penicillin G, phenytoin.
- Follow manufacturer's directions for further information on reconstitution, storage time, compatible IV fluids, and IV administration
Adverse Effects (≥1%)Body as a Whole:
Hypersensitivity [pruritus, urticaria, skin rashes, exfoliative and vesiculobullous dermatitis, erythema multiforme
angioedema, photosensitivity, anaphylactoid reaction, serum
sickness]; superinfections (proctitis, pruritus ani, vaginitis); vertigo, dizziness, headache, generalized myalgia,
thrombophlebitis following IV
use; pain at IM injection site. CV:
Hypotension, syncope, cardiopulmonary arrest
(particularly after rapid IV
, nausea, vomiting,
anorexia, decreased taste acuity, unpleasant or altered taste, abdominal cramps, diarrhea,
acute enterocolitis, pseudomembranous colitis (potentially fatal). Hematologic: Neutropenia
thrombocytopenic purpura, aplastic anemia. Special Senses:
InteractionsDrug: Kaolin and pectin
decrease lincomycin absorption; tubocurarine, pancuronium
may enhance neuromuscular blockade.
30 min IM. Duration:
1214 h IM; 14 h IV
High concentrations in bone, aqueous humor, bile, and peritoneal, pleural, and synovial fluids; crosses placenta; distributed
into breast milk. Metabolism:
Partially in liver. Elimination:
In urine and feces. Half-Life:
Assessment & Drug Effects
- Lab tests: Perform C&S initially and during therapy to determine continued microbial susceptibility. Periodic liver & kidney
function tests and CBC are indicated during prolonged drug therapy.
- Take a careful history of previous sensitivities to drugs or other allergens.
- Monitor BP and pulse. Have patient remain recumbent following drug administration until BP stabilizes.
- Monitor closely and report changes in bowel frequency. Discontinue drug if significant diarrhea occurs.
- Diarrhea, acute colitis, or pseudomembranous colitis (see Appendix F) may occur up to several weeks after cessation of therapy.
- Examine IM/IV injection sites daily for signs of inflammation.
- Monitor serum drug levels closely in patients with severe impairment of kidney function (levels tend to be higher).
- Superinfections by nonsusceptible organisms are most likely to occur when duration of therapy exceeds 10 d (see Appendix
Patient & Family Education
- Notify physician immediately of symptoms of hypersensitivity (see Appendix F). Drug should be discontinued.
- Notify physician promptly of the onset of perianal irritation, diarrhea, or blood and mucus in stools. Do not self-medicate
for diarrheaanti-diarrheal agents may prolong and worsen diarrhea by delaying removal of toxins from colon.
- Take drug as prescribed for full course of therapy.