Sevelamer decreases
levothyroxine absorption and appears to increase
levothyroxine requirements.
It would be prudent to monitor
levothyroxine requirements in patients requiring
sevelamer. Whether separation of
administration would minimise any interaction remains to be demonstrated, but, where absorption is a problem, the manufac- turers generally recommend avoiding giving other drugs at least 1 hour before or 3 hours after
sevelamer.