(LEE voe LOO koe voe rin) Brand: Fusilev
• You must not receive this medicine if you are allergic to levoleucovorin or to folic acid or folinic acid.
• If possible, till you receive levoleucovorin, speak your doctor or caregivers if you have kidney or liver malady, or if you are dehydrated.
• Speak your doctor if you are taking sulfa drugs, seizure medicine, a cancer medicine called fluorouracil (5FU), or a multivitamin or mineral supplement than contains folic acid.
• In an abnormal situation, it may not be possible till you are treated to speak your caregivers about all of your medical conditions or if you are pregnant or breast-feeding. However, create certain any doctor caring for you afterward knows that you have received this medication.
• Speak your doctor or caregivers at once if you have fever, chills, white patches or sores internal your mouth or on your lips, severe or ongoing diarrhea, confusion, urination problems, or if you feel very thirsty or hot, if you are unable to urinate, and you have hard sweating or hot and dry skin.
• Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.
• Levoleucovorin is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized. Levoleucovorin may also be used to treat toxic effects of an accidental overdose of methotrexate.
• Levoleucovorin is also used in combination chemotherapy with fluorouracil (5-FU, Adrucil, Efudex, Carac, Fluoroplex) to treat colorectal cancer that has spread to another parts of the body. Levoleucovorin treats only the symptoms of colorectal cancer but does not treat the cancer itself.
• Levoleucovorin must not be used to treat anemia that is caused by a lack of vitamin B12.
• Levoleucovorin may also be used for purposes not listed in this medicine guide.
• You must not receive this medicine if you are allergic to levoleucovorin or to folic acid or folinic acid.
• If possible, till you receive levoleucovorin, speak your doctor or caregivers if you have:
· kidney disease;
· liver malady; or
· if you are dehydrated.
• FDA pregnancy category C. It is not known whether levoleucovorin will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• It is not known whether levoleucovorin passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using levoleucovorin.
• In an abnormal situation, it may not be possible till you are treated with levoleucovorin to speak your caregivers if you are pregnant or breast feeding. Create certain any doctor caring for your pregnancy or your child knows you have received this medication.
• Levoleucovorin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Levoleucovorin should be given slowly, and the IV infusion can take up to 4 hours to complete.
• When treating or preventing methotrexate toxicity, levoleucovorin is generally given each 6 hours for 10 doses. You will most likely receive your first doze 24 hours after the start of your methotrexate infusion, or as soon as possible within the first 24 hours after accidental overdose.
• After treatment with levoleucovorin, you will be watched to create certain the medicine has been effective and you no longer have any effects of methotrexate.
• When treating colorectal cancer levoleucovorin is generally given daily as a 5-day treatment, repeated each 4 to 5 weeks.
• To be certain this medicine is helping your condition and is not causing deleterious effects, your blood will need to be tested often. This will help your doctor determine if your doze needs to be adjusted and how long to treat you with levoleucovorin. Visit your doctor regularly.
• If this medicine is given by a healthcare professional in an abnormal setting, you are not likely to miss a doze.
• If you are receiving levoleucovorin daily in 4-week treatment cycles, call your doctor for instructions if you miss an appointment for your scheduled injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Follow your doctor's instructions about any restrictions on food, beverages, or activity.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Speak your doctor or caregivers at once if you have a serious side effect such as:
· white patches or sores internal your mouth or on your lips;
· urinating more or smaller than usual;
· severe or ongoing diarrhea;
· feeling very thirsty or hot, being unable to urinate, hard sweating, or hot and dry skin;
· fever, chills;
· confusion; or
· trouble breathing.
• Smaller serious side effects may include:
· nausea, vomiting, diarrhea;
· stomach pain, upset stomach;
· numbness or tingling;
· loss of appetite, unusual or unpleasant taste in your mouth;
· weakness, weary feeling;
· hair loss; or
· mild skin rash.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• The next drugs can interact with levoleucovorin. Speak your doctor if you are using any of these:
· sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others);
· seizure medicine such as phenobarbital (Solfoton), phenytoin (Dilantin), or primidone (Mysoline); or
· a multivitamin or mineral supplement than contains folic acid.
• This list is not complete and another drugs may interact with levoleucovorin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about levoleucovorin.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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