LEVODOPA AND METHYLDOPA

Methyldopa can increase the effects of levodopa. This has allowed a dosage reduction of about 30 to 70% in some patients taking levodopa alone, but it can also worsen dyskinesias in others. A small increase in the hypotensive actions of methyldopa may also occur.
This interaction is expected to be minimised in the presence of carbidopa or benserazide and so it seems unlikely that a dose reduction of levodopa would usually be required. The increased hypotensive effects seem to be small, but be aware they are possible.