(lah RAH nih daze) Brand: Aldurazyme
• You must not use laronidase if you are allergic to it.
• Till you receive laronidase, speak your doctor if you have heart malady, kidney malady, lung malady, seizures, migraine headaches, or sleep apnea.
• Speak your doctor if you have been sick with a fever, head cool, or chest cool. You may need to wait before you get better till receiving your doze of laronidase.
• Some people receiving a laronidase have had a reaction to the infusion (when the medication is injected into the vein). Speak your caregiver right away if you have a headache, skin rash or itching, warmth or tingly feeling, or trouble breathing when laronidase is injected.
• Your doctor may also prescribe another medications to help prevent an allergic reaction to laronidase. Take all of your medications as directed.
• Laronidase is used to treat some of the symptoms of a genetic condition called Hurler syndrome, also called mucopolysaccharidosis (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis), or MPS I. Forms of MPS I include Hurler syndrome, Hurler-Scheie syndrome, and Scheie syndrome."
• MPS I is a metabolic mess in which the body lacks the enzyme needed to interrupt down determined sugars and proteins. These substances can build up in the body, causing enlarged organs, emergency bone structure, changes in facial parameters, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities.
• Laronidase may improve breathing and walking capacity in people with this condition. However, this medicine is not a cure for MPS I.
• Laronidase may also be used for purposes not listed in this medicine guide.
• You must not use laronidase if you are allergic to it.
• To create certain laronidase is safety for you, speak your doctor if you have any of these another conditions:
· fever or cool symptoms (cough, sore throat, chest congestion, sinus pain, runny or stuffy nose, sneezing);
· kidney disease;
· asthma or another lung disease;
· epilepsy or another seizure disorder;
· migraine headaches; or
· if you have sleep apnea and you use a continuous positive airway pressure (CPAP) car.
• You may be encouraged to join a patient registry while you are using this medicine. The purpose of this registry is to track the progression of this mess and the effects that laronidase has on long-term treatment of MPS I.
• FDA pregnancy category B. Laronidase is not expected to harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.
• If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to estimate any effects of laronidase on the baby.
• It is not known whether laronidase passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• Laronidase is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.
• The medication should be given slowly through an IV infusion, and can take up to 4 hours to complete.
• Laronidase is generally given once for week. Follow your doctor's instructions very carefully.
• Speak your doctor if you have been sick with a fever, head cool, chest cool. You may need to wait before you get better till receiving your doze of laronidase.
• Your doctor may also prescribe another medications to help prevent an allergic reaction to laronidase. Take all of your medications as directed.
• Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.
• Contact your doctor if you miss an appointment for your laronidase injection.
• Since laronidase is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
• Follow your doctor's instructions about any restrictions on food, beverages, or activity.
• Some people receiving a laronidase have had a reaction to the infusion (when the medication is injected into the vein). Speak your caregiver right away if you have a headache, skin rash or itching, warmth or tingly feeling, pale skin, or trouble breathing when laronidase is injected.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; slow heartbeats; feeling like you might pass out; swelling of your person, lips, tongue, or throat.
• Speak your caregivers at once if you have a serious side effect such as:
· chest pain;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· fever, chills, rapid heart course; or
· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, shortness of breath, uneven heartbeats, seizure).
• Smaller serious side effects may include:
· mild skin rash;
· overactive reflexes;
· numbness or tingling;
· cool symptoms such as runny or stuffy nose, sneezing, sore throat; or
· pain, redness, swelling, or another irritation where the medication was injected.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• There may be another drugs that can interact with laronidase. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about laronidase.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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