LAMOTRIGINE (LAMICTAL)

Lamotrigine (Lamictal); Anticonvulsant; Tab: 25, 100, 150, 200 mg
Tab, chew: 2, 5, 25 mg; Round all doses to nearest tablet size.
Adding to regimen containing valproic acid:
2-12 yrs: 0.15 mg/kg/day PO qd-bid weeks 1-2, then increase to 0.3 mg/kg/day PO qd-bid weeks 3-4, then increase q1-2 weeks by 0.3 mg/kg/day to
usual maintenance dose 1-5 mg/kg/day qd-bid (max 200 mg/day)
>12 yrs: 25 mg PO qOD weeks 1-2, then increase to 25 mg PO qd weeks 3-4, then increase q1-2 weeks by 25-50 mg/day to maintenance dose 100-
400 mg/day PO qd-bid
Adding to enzyme-inducing antiepileptic regimen without valproic acid:
2-12 yrs: 0.6 mg/kg/day PO bid during weeks 1-2, then increase to 1.2 mg/kg/day PO bid weeks 3-4, then increase q1-2 weeks by 1.2 mg/kg/day to
usual maintenance dose 5-15 mg/kg/day PO bid (max 400 mg/day)
>12 yrs: 50 mg PO qd during weeks 1-2, then increase to 50 mg PO bid weeks 3-4, then increase q1-2 weeks by 100 mg/day to usual maintenance
dose 300-500 mg/day PO bid
Round dose down to the nearest 5 mg to use whole tablets.