Lopinavir/ritonavir halved
lamotrigine plasma levels, whereas the
protease inhibitor levels did not appear to be altered. Saquinavir/ritonavir had similar effects in another patient and therefore reduced
lamotrigine levels should be anticipated with any ritonavir-boosted regimen.
Lamotrigine efficacy should be monitored in patients taking
lopinavir/ritonavir, and probably any ritonavir-boosted regimen. Anticipate the need to increase the
lamotrigine dose.