Isoniazid (INH, Laniazid, Nydrazid); Tuberculostatic; Inj: 100 mg/mL
Syr: 10 mg/mL
Tab: 100, 300 mg;
Active Tuberculosis: 10-15 mg/kg/day PO/IM qd-bid (max 300 mg/day).
Prophylaxis: 10 mg/kg/day PO/IM qd (max 300 mg/day)
American Thoracic Society and CDC recommend twice-weekly oral therapy as part of a short-course regimen, which follows 1-2 months of daily
treatment:
Children: 20-30 mg/kg/dose (up to 900 mg/dose) twice weekly
May cause severe
hepatitis. Pyridoxine 1-2 mg/kg/day PO qd prevents peripheral
neuropathy.