ISONIAZID AND PARACETAMOL (ACETAMINOPHEN)

Hepatotoxicity has been seen with the combination of isoniazid and paracetamol, usually in patients who have taken more than 4 g of paracetamol daily, but occasionally in those taking normal doses.
The ultra-cautious may wish to limit paracetamol intake, but information is very limited and more study is needed to confirm any interaction.