| ISOETHARINE HYDROCHLORIDE
Classifications: beta-adrenergic agonist; bronchodilator; Therapeutic: bronchodilator; beta-adrenergic agonist
Pregnancy Category: C
Synthetic sympathomimetic stimulant with relatively rapid onset and long duration of action. Has selective affinity for
beta2-adrenoreceptors on bronchial and selected arteriolar musculature. Relieves reversible bronchospasm and by bronchodilation
facilitates expectoration of pulmonary secretions. Increases vital capacity and decreases airway resistance.
Effective in relieving brochospasms as well as facilitating expectoration of respiratory secretions.
Bronchial asthma and reversible bronchospasm occurring with bronchitis and emphysema.
Known hypersensitivity to sympathomimetic amines and to bisulfites; concomitant use with epinephrine or other sympathomimetic
amines; patients with preexisting cardiac arrhythmias associated with tachycardia; pregnancy (category C).
Older adults; hypertension; acute coronary artery disease; CHF; cardiac diseases; asthma; hyperthyroidism, diabetes mellitus;
tuberculosis; history of seizures.
Route & Dosage
Adult: Inhalation 0.51 mL 0.5% or 0.5 mL 1% solution diluted 1:3 with normal saline or 24 mL 0.125% solution undiluted
or 25 mL 0.2% solution undiluted or 2 mL 0.25% solution undiluted per nebulizer q4h (max: 5 times/d); 12
inhalations from an MDI q4h up to 5 times/d
Child: Inhalation 0.01 mL/kg of 1% solution (max: 0.5 mL) diluted in 23 mL normal saline
- Give on arising in morning and before meals to reduce fatigue from activity by improving lung ventilation.
- Wait 1 full min after initial 1 or 2 inhalations (Bronkometer) to be sure of necessity for another dose. Action should begin
immediately and peak within 515 min.
- Alternate therapy with concurrent epinephrine administration but do not administer simultaneously because of danger of excessively
- Do not use discolored or precipitated solutions.
- Protect solutions from light, freezing, and heat.
Adverse Effects (≥1%)CV: Tachycardia, palpitations,
changes in BP, cardiac arrest. GI:
Nausea, vomiting. CNS:
tension, restlessness, insomnia
weakness, dizziness, excitement. Respiratory:
Cough, bronchial irritation and edema; tachyphylaxis.
Interactions Drug: Epinephrine,
other sympathomimetic bronchodilators
possibly have additive effects; mao inhibitors
, tricyclic antidepressants
potentiate action on vascular system; effects of both beta-adrenergic blockers
and isoetharine antagonized when given together.
515 min. Duration:
14 h. Metabolism:
In lungs, liver, GI tract, and other tissues. Elimination:
Excreted by kidneys.
Assessment & Drug Effects
- Do not use this product if patient has a history of allergy to sulfite agents. The preservative sodium bisulfite is in the
- Monitor cardiac status and report tachycardia and palpitations. Older adults may be especially sensitive to adrenergic drug
Patient & Family Education
- Close eyes when actuating the nebulizer.
- Use inhalation therapy according to prescribed regimen. Overuse may decrease desired effect and cause symptoms including
tachycardia, palpitations, headache, nausea, dizziness.
- Read information and instructions furnished with the aerosol form of isoetharine.
- Increase daily fluid intake to aid in liquefaction of bronchial secretions.
- Discontinue drug and notify physician if a sudden increase in dyspnea occurs.
- Do not discard drug applicator. Refill units are available.