Ferrous fumarate, gluconate, sulfate and other iron compounds can reduce the absorption of ciprofloxacin, gatifloxacin, levofloxacin, norfloxacin, ofloxacin and sparfloxacin. Serum levels of the antibacterial may become subtherapeutic as a result.
Most quinolones should not be taken at the same time as iron. Since the quinolones are rapidly absorbed, taking them 2 hours before the iron should largely avoid this interaction. The exceptions are fleroxacin, which appears not to interact, and lomefloxacin, which seems to interact only minimally.
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