IRON AND LEVODOPA

The absorption of levodopa can be reduced by 30 to 50% by ferrous sulfate due to levodopa chelation. Therefore all iron compounds are expected to act similarly. Carbidopa levels are also reduced. There is some evidence that this interaction causes a decrease in symptom control.
Separating the administration of the iron as much as possible is likely to be an effective way of managing this interaction.
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