Classifications: hormone; antidiabetic agent; insulin rapid-acting; Therapeutic: antidiabetic; insulin rapid-acting
Prototype: Insulin injection (Regular)
Pregnancy Category: C
100 units/mL multidose (10 mL) vials
Insulin glulisine, formed by recombinant DNA, is a rapid-acting insulin. Insulin lowers blood glucose by stimulating peripheral
glucose uptake by skeletal muscle and fat and by inhibiting hepatic glucose production. Insulin causes lipolysis in the adipocytes,
inhibits proteolysis, and enhances protein synthesis.
Insulin glulisine has a more rapid onset of action and a shorter duration of action than regular human insulin; thus, it
provides good postprandial blood glucose control.
Treatment of diabetes mellitus.
Hypoglycemia; systemic allergy to insulin; pregnancy (category C).
Renal impairment, hepatic dysfunction; thyroid disease; fever; older adults; children; lactation.
Route & Dosage
Adult: SC 510 units within 15 min before starting a meal or within 20 min after starting a meal. Dose should be individualized.
- Give within 15 min before or up to 20 min after a meal.
- Store refrigerated at 36° F to 46° F (2° C to 8° C). Discard vial if frozen. Protect from light.
Adverse Effects (≥1%)[See INSULIN (REGULAR)] Body as a Whole:
Allergic reactions. Metabolic: Hypoglycemia
Injection site reactions, lipodystrophy, pruritus, rash.
Diagnostic Test Interference
See INSULIN INJECTION (REGULAR).
70% bioavailable from injection sites. Onset:
1530 min. Peak:
55 min. Duration:
34 h. Metabolism:
In liver with some metabolism
in the kidney. Half-Life:
42 min SC.
Assessment & Drug Effects
- Monitor for S&S of hypoglycemia (see Appendix F). Initial hypoglycemic response begins within 15 min and peaks, on average,
4060 min after injection.
- Lab tests: Periodically monitor fasting and postprandial blood glucose and HbA1C.
Patient & Family Education
- Do not inject into areas with redness, swelling, itching, or dimpling.
- If mixing with NPH human insulin, draw up insulin glulisine first. Inject immediately after mixing.
- Ingest some form of sugar (e.g., orange juice, dissolved table sugar, honey) if symptoms of hypoglycemia develop, and seek
- Check blood sugar as prescribed, especially postprandial values; notify physician of fasting blood glucose <80 and >140
- Notify the physician of any of the following: fever, infection, trauma, diarrhea, nausea, or vomiting. Dosage adjustment
may be needed.
- Do not take any other medication unless approved by the physician.