Imipramine (Tofranil); Tricyclic Antidepressant; Cap: 75, 100, 125, 150 mg
Tab: 10, 25, 50 mg;
Depression: 1.5 mg/kg/day PO with dosage increments of 1 mg/kg/day q3-4days to max dose of 5 mg/kg/day qd-qid.
Enuresis: >6 years: Initial: 10-25 mg PO qhs x 1 wk; if inadequate response, increase by 25 mg/day to max 2.5 mg/kg/day or 50 mg qhs if 6-12 yrs or
75 mg qhs if >12 yrs.
Adolescents: Initial: 25-50 mg/day PO; max 200 mg/day in single or divided doses
Therapeutic
serum levels (imipramine and desipramine): 150-250 ng/mL