Case reports describe reduced valproate
levels after imipenem
was given. This has led to seizures.
Although evidence is limited this is in line with the way other carbapenems interact. It would be prudent to monitor valproate
levels in any patient given carbapenems. The valproate
dosage may need to be increased. Consider using another antibacterial, or an alternative to valproate
. Limited evidence suggests that carbamazepine
are not affected. Note that imipenem
be used with caution in patients with a history of seizures.