IMATINIB AND MACROLIDES

Ketoconazole increases the AUC of imatinib by 40%. Macrolides such as erythromycin and clarithromycin are, like ketoconazole, inhibitors of CYP3A4. The manufacturers of imatinib therefore predict that the macrolides will raise imatinib levels.
It is not clear what action should be taken as information about the effects of increased imatinib levels is limited. Other macrolides may also interact, although it seems unlikely that they all will, see macrolides.
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