Classifications: prostaglandin; antihypertensive, pulmonary; Therapeutic:pulmonary antihypertensive
Pregnancy Category: C
2 mcg/2 mL ampule
Iloprost is a synthetic analog of prostaglandin. It dilates systemic and pulmonary arterial vascular beds.
Dilation of the pulmonary arterial vessels reduces pulmonary hypertension.
Treatment of pulmonary arterial hypertension in patients with New York Heart Association (NYHA) class III or IV symptoms.
Treatment of severe Raynaud phenomenon associated with systemic sclerosis.
Systolic blood pressure <85 mm Hg; pregnancy (category C), lactation; children.
Impaired hepatic function, elderly, renal impairment with inhaled iloprost; asthma, acute respiratory infection, COPD; elderly;
dialysis, concurrent use of vasodilators and/or antihypertensive drugs.
Route & Dosage
Adult: Inhaled 2.55 mcg 69 times daily, but no more than q2h during waking hours
- Transfer the contents of one ampule to the drug delivery system medication chamber immediately before use. Follow instructions
provided by manufacturer for the delivery system. Do not allow contact with skin or eyes.
- Do not administer if systolic BP is <85 mg Hg.
- Do not administer any sooner than 2 h after the previous dose.
- Discard any solution remaining in the medication chamber after the inhalation session.
- Store at 20°25° C (68°77° F).
Adverse Effects (≥1%)CNS: Headache, insomnia
. CV: Hypotension, vasodilation
), palpitations, syncope, chest pain, tachycardia,
congestive heart failure. GI: Nausea, vomiting. Hepatic:
Increased alkaline phosphatase, increased gamma-glutamyltransferase (GGT). Musculoskeletal:
Back pain, muscle cramps, trismus. Renal:
Kidney failure. Respiratory: Cough,
dyspnea, hemoptysis, pneumonia
, peripheral edema. Body as a Whole: Flu-like syndrom
e, tongue pain.
Enhanced hypotension when given with other vasodilators
agents; increased risk of bleeding when given with other anticoagulants
60% protein bound. Metabolism:
Completely metabolized to inactive products. Elimination:
Urine (major) and feces. Half-Life:
Assessment & Drug Effects
- Supervise ambulation, especially with concurrent use of other drugs known to cause dizziness or syncope.
- Monitor vital signs closely during initiation of drug therapy.
- Monitor for and report S&S of heart failure.
- Withhold drug and notify physician if S&S of pulmonary edema appear.
- Lab tests: Monitor blood levels of anticoagulants when used concurrently.
Patient & Family Education
- Follow directions for taking the drug (see Administration). Iloprost inhalation should be used with the Prodose AAD system.
Do not use it with other types of nebulizers.
- Make position changes slowly, especially when arising from a chair or bed.
- Do not drive or engage in potentially hazardous activities until response to drug is known.
- Report any of the following to a health care provider: dizziness or fainting, especially upon exertion, or increased difficulty