HEPATITIS B VACCINE (RECOMBINANT) (hep'a-ti-tis) Engerix-B, Recombivax HB Classifications: vaccine; Therapeutic: vaccine Pregnancy Category: C |
10 mcg/mL, 5 mcg/0.5 mL, 40 mcg/mL (Recombivax); 20 mcg/mL, 10 mcg/0.5 mL (Engerix-B)
Suspension of inactivated and purified hepatitis B surface antigen (HBsAg) derived from human plasma of screened asymptomatic HBsAg-positive carriers of hepatitis B virus. Hepatitis B vaccine recombinant is the first vaccine produced by gene splicing. No human plasma is used in its production.
The recommended 3-dose regimen produces active immunity against hepatitis B infection by inducing protective antibody (anti-HBs) formation.
To promote active immunity in individuals at high risk of potential exposure to hepatitis B virus or HBsAg-positive materials. Has been used simultaneously (into different sites) with hepatitis B immune globulin (H-BIG) for post-exposure prophylaxis in selected patients and in infants born to HBsAg-positive mothers.
History of allergic reaction to hepatitis B vaccine or to any ingredient in the formulation; HBsAg carriers; pregnancy (category C).
Compromised cardiopulmonary status, serious active infection or fever; renal disease, renal failure; thrombocytopenia or other bleeding disorders; lactation.
Hepatitis B Prophylaxis Adult: IM Recombivax 1 mL (10 mcg) at 0, 1, and 6 mo; Engerix-B 1 mL (20 mcg) at 0, 1, and 6 mo or 0, 1, 2, and 12 mo Child: IM Recombivax 0.5 mL (5 mcg) at 0, 1, and 6 mo; Engerix-B 0.5 mL (10 mcg) at 0, 1, and 6 mo or 0, 1, 2, and 12 mo Dialysis and Immunodeficient Patients Adult: IM Recombivax 2 mL (20 mcg) at 0, 1, and 6 mo; Engerix-B 2 mL (40 mcg) at 0, 1, and 6 mo or 0, 1, 2, and 12 mo |
Assessment & Drug Effects
Patient & Family Education