| HAEMOPHILUS b CONJUGATE VACCINE (HiB)
HibTITER, PedvaxHIB, ProHIBiT
Classifications: vaccine; Therapeutic: vaccine
Prototype: Hepatitis B vaccine
Pregnancy Category: C
7.5 mcg, 10 mcg, 15 mcg, 25 mcg injection
A highly purified capsular polysaccharide extracted from Haemophilus influenzae type b (Hib). Hib, principal antigen in the vaccine, promotes production of Hib anticapsular antibodies. It mediates complement-dependent
bacteriolyses of H. influenzae type b organism.
The vaccine produces antibodies effective against H. influenza type b.
To provide active immunity to H. influenzae type b (Hib) infection in children 2 mo5 y.
Adults at risk of Hib infection who have Hodgkin's disease, before immunosuppressive chemotherapy.
Hypersensitivity to any component of vaccine (e.g., thiomersal); febrile illness (other than upper respiratory tract infection);
active infection; immunosuppression; infants <2 mo; pregnancy (category C).
Route & Dosage
|Immunoprophylaxis for H. influenzae type b Infection
Child: IM 26 mo, HibTITER 0.5 mL, 3 doses 2 mo apart with booster at 15 mo; PedvaxHIB 0.5 mL, 2 doses 2 mo apart with booster at 12 mo; 711 mo, HibTITER 0.5 mL, 2 doses 2 mo apart with booster at 15 mo; PedvaxHIB 0.5 mL, 2 doses 2 mo apart with booster at 15 mo; 1214 mo, HibTITER 0.5 mL, 1 dose with booster at 15 mo; PedvaxHIB 0.5 mL, 1 dose with booster at 15 mo; 15 mo5 y, all vaccines 0.5 mL as 1 dose
- Reconstitute lyophilized powder with supplied diluent.
- Note: Use different sites when giving Hib polysaccharide vaccine and DPT (diphtheria, pertussis, tetanus) at the same time.
- Store at 2°8° C (36°46° F); may be frozen without loss of potency. Do not freeze the diluent.
Adverse Effects (≥1%)Skin:
Irritation at injection site (49%). Other:
Acute febrile reactions (13%), irritability, anorexia, anaphylactoid reaction
Diagnostic Test Interference
Hib polysaccharide vaccine may interfere with interpretation of antigen detection tests (e.g., latex agglutination) used in diagnosis of systemic Hib disease.
InteractionsDrug: immunosuppressant drugs
may decrease antibody response.
Antibody levels detected within 2 wk. Peak:
3 wk. Duration:
1.53.5 y. Distribution:
Crosses placenta; distributed into breast milk.
Assessment & Drug Effects
- Be prepared for anaphylactoid reaction (see Appendix F) by having epinephrine 1:1000 available.
Patient & Family Education
- Note: Local reactions to the vaccine at the injection site (erythema, tenderness, induration, swelling, pain) may appear within
6 h after administration; usually symptoms are mild and disappear in 24 h.
- Monitor temperature after injection. An acute febrile reaction with temperature above 38.3° C (101° F) may follow
vaccination (less than 1% of recipients). Notify physician.