H2-RECEPTOR ANTAGONISTS AND TACRINE

Cimetidine increases the plasma levels of tacrine by up to about 50%.
An increase in the effects and possibly adverse effects of tacrine (nausea, vomiting, diarrhoea) seems possible. In one interaction study, a patient had to be withdrawn due to nausea and vomiting caused by this combination. Monitor concurrent use for adverse effects.
(10)
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