GRAPEFRUIT JUICE AND SIROLIMUS

The manufacturers of sirolimus predict that grapefruit juice may raise its serum levels,
probably because ketoconazole has been shown to do so (both ketoconazole and grapefruit juice can inhibit CYP3A4 by which sirolimus is metabolised).
The extent of any change in sirolimus levels is uncertain. The manufacturers suggest that concurrent use should be avoided.
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