GOSERELIN ACETATE (gos-er'e-lin) Zoladex Classifications: hormone; gonadotropin-releasing hormone (gnrh) analog; Therapeutic: gnrh analog Prototype: Leuprolide Pregnancy Category: X |
3.6 mg, 10.8 mg SC implant
A synthetic form of luteinizing hormone-releasing hormone (LHRH or GnRH) that inhibits pituitary gonadotropin secretion.
With chronic administration, serum testosterone levels fall into the range normally seen with surgically castrated men.
Prostate cancer, breast cancer. Endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
Endometriosis, uterine leiomyomas.
Known hypersensitivity to an LHRH; vaginal bleeding; endometriosis or endometrial thinning; hypercalcemia; pregnancy (category X); lactation.
Urinary tract obstruction and children; family history of osteoporosis; concurrent use with anticonvulsants or corticosteroids; osteoporosis; patients at risk for spinal cord compression or urinary tract obstruction. Safety and efficacy in children are not established.
Prostate Cancer, Breast Cancer, Endometriosis, Uterine Leiomyomas Adult: SC 3.6 mg once q28d, 10.8 mg depot q12wk Endometrial Thinning Prior to Endometrial Ablation Adult: SC 3.6 mg once q28d |
Increased levels of alkaline phosphatase and estradiol in the first 18 d; initial increase then decrease in FSH, LH, and testosterone.
Assessment & Drug Effects
Patient & Family Education