Fleet Babylax, Glycerol, Osmoglyn
Classifications: fluid and electrolyte agent; hyperosmotic laxative; antiglaucoma; Therapeutic:hyperosmotic laxative; antiglaucoma
Pregnancy Category: C
50% oral solution; suppositories; 4 mL/applicator, ophthalmic solution
When administered orally, glycerin raises plasma osmotic pressure by withdrawing fluid from extravascular spaces; lowers ocular
tension by decreasing volume of intraocular fluid. May also reduce CSF pressure. Topical application to eye reduces edema
by hydroscopic effect. Glycerin suppositories apparently work by causing dehydration of exposed tissue, which produces an
irritant effect, and by absorbing water from tissues, thus creating more bowel mass. Both actions stimulate peristalsis in
the large bowel.
Reduces intraocular pressure by lowering intraocular fluid. Relieves constipation by absorption of water and stimulation of
Orally to reduce elevated intraocular pressure (IOP) before or after surgery in patients with acute narrow-angle glaucoma,
retinal detachment, or cataract and to reduce elevated CSF pressure. Sterile glycerin (anhydrous) is used topically to reduce
superficial corneal edema resulting from trauma, surgery, or disease and to facilitate ophthalmoscopic examination. Used rectally
(suppository or enema) to relieve constipation.
To reduce mortality due to strokes in older adults.
Diabetic ketoacidosis; moderate or severe renal impairment (Clcr <50 mL/min), renal failure; pregnancy (category C); lactation.
Cardiac disease, mild renal impairment; hepatic disease; diabetes mellitus; thyroid disease; dehydrated or older adult patients.
Route & Dosage
Adult/Child: PO 11.8 g/kg 11.5 h before ocular surgery, may repeat q5h
Adult/Child (≥6 y): PR Insert 1 suppository or 515 mL of enema high into rectum and retain for 15 min
Child (<6 y): PR Insert 1 infant suppository or 25 mL of enema high into rectum and retain for 15 min
Neonate: PR 0.5 mL of rectal solution (enema)
Reduction of Corneal Edema
Adult: Topical 12 drops instilled into eye q34h
- Pour commercially available flavored solution over crushed ice, then sip through a straw. Lemon or lime juice and NS (if allowed)
may be added to unflavored solution for palatability.
- Prevent or relieve headache (from cerebral dehydration) by having patient lie down during and after administration of drug.
- Ensure that suppository is inserted beyond rectal sphincter.
Adverse Effects (≥1%)CNS:
Headache, dizziness, disorientation. CV:
Irregular heartbeat. GI:
Nausea, vomiting, thirst, diarrhea, abdominal cramps, rectal discomfort, hyperemia of rectal mucosa. Metabolic:
Hyperglycemia, glycosuria, dehydration, hyperosmolar nonketotic coma
Readily absorbed from GI tract after oral administration; rectal preparations are poorly absorbed. Onset:
10 min PO. Peak:
30 min2 h. Duration:
48 h. Metabolism:
80% metabolized in liver; 1020% metabolized in kidneys to CO2
and water or utilized in glucose or glycogen synthesis. Elimination:
714% excreted unchanged in urine. Half-Life:
Assessment & Drug Effects
- Consult physician regarding fluid intake in patients receiving drug for elevated IOP. Although hypotonic fluids will relieve
thirst and headache caused by the dehydrating action of glycerin, these fluids may nullify its osmotic effect.
- Monitor glycemic control in diabetics. Drug may cause hyperglycemia (see Appendix F).
Patient & Family Education
- Evacuation usually comes 1530 min after administration of glycerin rectal suppository or enema.
- Note: Slight hyperglycemia and glycosuria may occur with PO use; adjustment in antidiabetic medication dosage may be required.