(gloo KAR pi dase) Brand: Voraxaze
• If possible till you receive glucarpidase, speak your doctor if you are also being treated with leucovorin. In an abnormal situation it may not be possible to speak your caregivers about your health conditions. Create certain any doctor caring for you afterward knows you have received this medicine.
• Speak your caregiver right away if you have any symptoms of a reaction to the glucarpidase injection: severe dizziness or weakness, severe nausea, cool sweat, itching, numbness or tingly feeling, sudden headache, quick heartbeats, chest tightness, trouble breathing, or if you feel like you might pass out.
• Glucarpidase is used in patients who develop kidney failure while receiving tall doses of methotrexate (a chemotherapy drug).
• Glucarpidase is an enzyme that breaks down methotrexate in the body so the drug can be easily eliminated when the kidneys are not working properly.
• Glucarpidase may also be used for purposes not listed in this medicine guide.
• If possible till you receive glucarpidase, speak your doctor if you are also being treated with leucovorin.
• FDA pregnancy category C. It is not known whether glucarpidase will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• It is not known whether glucarpidase passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• In an abnormal situation it may not be possible to speak your caregivers if you are pregnant or breast feeding. Create certain any doctor caring for your pregnancy or your child knows you have received this medication.
• Glucarpidase is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Glucarpidase is generally given as a single injection. The IV infusion will take about 5 minutes to complete.
• Drink plenty of fluids to hold yourself hydrated while you are using glucarpidase. Follow your doctor's instructions about the type and amount of liquids you must drink.
• To create certain this medicine is helping your condition and not causing deleterious effects, your blood will need to be tested often. Do not miss any follow-up visits to your doctor.
• Since glucarpidase is used as a single doze, it does not have a daily dosing schedule.
• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
• Follow your doctor's instructions about any restrictions on food, beverages, or activity.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Some people receiving a glucarpidase injection have had a reaction to the infusion (when the medication is injected into the vein). Speak your caregiver right away if you have:
· severe dizziness or weakness;
· severe nausea, feeling like you might pass out;
· cool sweat, itching, numbness or tingly feeling;
· sudden headache;
· quick heartbeats, chest tightness; or
· trouble breathing.
• General side effects may include:
· mild nausea;
· mild headache; or
· mild numbness or tingling.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Another drugs may interact with glucarpidase, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Speak every of your health care providers about all medicines you use, especially leucovorin.
• Your pharmacist can provide more information about glucarpidase.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.