Ganciclovir (Cytovene);
Antiviral; Cap: 250, 500 mg
Inj: 500 mg;
Cytomegalovirus Retinitis: Induction: 10 mg/kg/day
IV bid x 14-21 days. Maintenance: 5 mg/kg/day
IV q24h x 7 days/week or 6
mg/kg/day
IV q24h x 5 days/week
Oral maintenance
following
IV induction: 6 mos-16 yrs: 30 mg/kg/dose PO q8h, >16 yrs:
1000 mg tid or 500 mg q3h while awake (6 times daily)
Other CMV Infections:
Induction: 10 mg/kg/day
IV q12h or 7.5 mg/kg/day
IV q8h x 14-21 days
Oral maintenance
following
IV induction: 6 mos-16 yrs: 30 mg/kg/dose PO q8h, >16 yrs: 1000 mg tid or 500 mg q3h while awake (6 times daily)
Granulocytopenia and
thrombocytopenia; adjust dose in
renal failure. Extemporaneous suspension can be made.