Paroxetine increases the risk of galantamine adverse effects (in particular nausea and vomiting) probably by inhibiting the metabolism of galantamine by CYP2D6. The manufacturers therefore predict that other CYP2D6 inhibitors (such as fluoxetine) will interact similarly. They also name fluvoxamine but note that fluvoxamine is usually considered to be a weak inhibitor of this isoenzyme.
If the adverse effects of galantamine develop or worsen, reduce its dose.
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