Paroxetine increases the risk of
galantamine adverse effects (in particular nausea and vomiting) probably by inhibiting the
metabolism of
galantamine by CYP2D6. The manufacturers therefore predict that other CYP2D6 inhibitors (such as fluoxetine) will interact similarly. They also name
fluvoxamine but note that
fluvoxamine is usually considered to be a weak inhibitor of this isoenzyme.
If the adverse effects of
galantamine develop or worsen, reduce its dose.