Paroxetine increases the risk of galantamine
adverse effects (in particular nausea and vomiting) probably by inhibiting the metabolism
by CYP2D6. The manufacturers therefore predict that other CYP2D6 inhibitors (such as fluoxetine) will interact similarly. They also name fluvoxamine
but note that fluvoxamine
is usually considered to be a weak inhibitor of this isoenzyme.
If the adverse effects of galantamine
develop or worsen, reduce its dose.