| FOSFOMYCIN TROMETHAMINE
Classifications: antibiotic; Therapeutic: antibiotic; urinary tract antiinfective
Pregnancy Category: B
3 g packets
Synthetic, broad-spectrum, bactericidal antibiotic active against gram-negative and gram-positive aerobic organisms that blocks
the first steps in bacterial cell wall synthesis.
Acts as a bactericidal agent against Enterococcus faecalis, E. faecium, and Escherichia coli. In addition, it is effective against Klebsiella, Proteus, and Serratia. Indicated by improvement in cystitis symptoms within 23 d.
Treatment of uncomplicated UTIs in women due to susceptible strains of E. coli and E. faecalis.
Hypersensitivity to fosfomycin.
Pregnancy (category B); lactation. Safety and efficiency in children <12 y are not established.
Route & Dosage
Adult: PO 3 g sachet dissolved in 34 oz of water as a single dose given once
- Pour entire contents of a single dose into 34 oz water (not hot), stir to dissolve completely, and give immediately.
Drug must not be taken in the dry form.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)Body as a Whole:
Pain. CNS: Headache,
dizziness. GI: Diarrhea,
nausea, abdominal pain, dyspepsia. Respiratory:
Rhinitis, pharyngitis. Urogenital: Vaginitis
may decrease urinary excretion of fosfomycin.
Rapidly from GI tract, 37% of dose reaches systemic circulation as free acid. Peak Urine Concentration:
24 h. Distribution:
Not protein bound, distributed to kidneys, bladder wall, prostate, and seminal vesicles. Elimination:
Primarily in urine. Half-Life:
Assessment & Drug Effects
- Lab tests: Obtain urine C&S before and after therapy.
Patient & Family Education
- Notify physician if symptoms do not improve in 23 d.