Food reduces the bioavailability of
lansoprazole and esomeprazole by up to 50%.
It is recommended that
lansoprazole should not be given with food. Giving
lansoprazole one hour before food is probably enough to avoid the interaction. Esomeprazole capsules and suspension should be taken one hour before meals, but food does not appear to alter the effects of esomeprazole tablets on gastric acidity.