Food increases the bioavailability of
atazanavir,
darunavir, lopinavir, nelfinavir, saquinavir, and
tipranavir, but decreases that of indinavir. Food only minimally affects the bioavailability of
amprenavir, fosamprenavir and
ritonavir.
Indinavir should be given one hour before or 2 hours after meals, or with light
meals only. Atazanavir,
darunavir, lopinavir, nelfinavir, and
tipranavir should be taken with food to enhance bioavailability. Saquinavir (soft and hard capsules) should be taken up to 2 hours after a meal. The US manufacturers of
amprenavir say that it should not be given with high-fat meals, but otherwise it may be given with or without food.