Classifications: ophthalmic diagnostic agent;
Therapeutic:ophthalmic diagnostic agent

Pregnancy Category: X


100 mg/mL injection


Mildly antiseptic fluorescent dye related chemically to phenolphthalein that demonstrates defects of the corneal epithelium.

Therapeutic Effect

Any break in the epithelial tissue allows the dye to enter the tissue. Epithelial damage will appear as a bright green area.


Used IV as a diagnostic aid in retinal angiography. Also used as an antidote for aniline dye.


Intraarterial administration; intrathecal administration; pregnancy (category X).

Cautious Use

History of hypersensitivity, allergies, bronchial asthma.

Route & Dosage

Retinal Angiography
Adult: IV 5 mL of 10% solution or 3 mL of 25% solution injected rapidly in antecubital vein
Child: IV 7.5 mg/kg injected rapidly in antecubital vein



ADMINISTER: IV Direct for Adult: 5 mL of 10% solution or 3 mL of 25% solution injected rapidly in antecubital vein.  IV Direct for Child: 7.5 mg/kg injected rapidly in antecubital vein.  

Adverse Effects (≥1%)

CNS: Headache, paresthesias, pyrexia, convulsions. CV: Hypotension, transient dyspnea, acute pulmonary edema, basilar artery ischemia, syncope, severe shock, cardiac arrest. GI: Nausea, vomiting, strong metallic taste following high dosage. Body as a Whole: Hypersensitivity (urticaria, pruritus, angioneurotic edema, anaphylactic reaction). Skin: Thrombophlebitis at injection site, temporary discoloration of skin and urine.

Nursing Implications

Assessment & Drug Effects

  • Have facilities for treatment of anaphylactic reaction immediately available (e.g., epinephrine 1:1000 for IV or IM use, an antihistamine, and oxygen).
  • Discontinue fluorescein immediately if S&S of sensitivity develop.

Patient & Family Education

  • Note: IV administration may impart a yellowish orange discoloration to skin and to urine. Skin discoloration usually fades in 6–12 h; urine clears in 24–36 h.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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