FLOXURIDINE

(flox URE i deen) Brand: FUDR

What is the most significant information I must know about floxuridine?

• You must not use floxuridine if you have an infection, bone marrow suppression, or if you are malnourished.

• Your doctor will want to give your first doze of this medication in a hospital or clinic setting to quickly treat any serious side effects that occur.

What is floxuridine?

Floxuridine is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Floxuridine is used in the treatment of digestive system cancers that have spread to the liver.

Floxuridine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till using floxuridine?

• You must not receive floxuridine if you are allergic to it, or if you have:

· an infection;

· bone marrow suppression; or

· if you are malnourished.

• To create certain floxuridine is safety for you, speak your doctor if you have:

· liver disease;

· kidney disease;

· if you have had radiation of your pelvic area; or

· if you have had previous treatment with another chemotherapy medicines.

• FDA pregnancy category D. Do not use floxuridine if you are pregnant. It could harm the unborn child. Use effective birth control to avoid pregnancy during your treatment with floxuridine. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.

• It is not known whether floxuridine passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.

How must I use floxuridine?

• Your doctor will want to give your first doze of this medication in a hospital or clinic setting to quickly treat any serious side effects that occur.

Floxuridine is injected into an artery through an infusion exhaust. A healthcare provider will give you this injection.

• You will be watched closely while receiving floxuridine, to create certain you do not have a severe reaction to the medicine. Your blood will also need to be tested during treatment.

Floxuridine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches, sores in your mouth or throat).

What happens if I miss a dose?

• Because you will receive floxuridine in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What must I avoid while using floxuridine?

• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.

• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.

Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

Do not receive a "live" vaccine while using floxuridine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the possible side effects of floxuridine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· pain or pressure in your chest, feeling light-headed, numbness or tingling anywhere in your body;

· fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;

· severe vomiting or diarrhea;

· bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or

· any bleeding that will not stop.

• General side effects may include:

· mild nausea or vomiting, mild diarrhea;

· temporary hair loss; or

· redness or irritation where the medication was injected.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect floxuridine?

• Another drugs may interact with floxuridine, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Speak every of your health care providers about all medicines you use now and any medication you start or stop using.

Where can I get more information?

• Your doctor or pharmacist can provide more information about floxuridine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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