Classifications: antihistamine; h1-receptor antagonist, non-sedating; Therapeutic: antihistamine; non-sedating h1-receptor antagonist
Pregnancy Category: C
30 mg, 60 mg, 180 mg tablets; 60 mg capsules; 30 mg orally disintegrating tablet
Competes with free histamine for binding at the H1-receptor. This competitive antagonism blocks effects of histamine on H1-receptors in bronchial smooth muscle. This also results in decreased formation of edema, flare, and pruritus that result
from histaminic activity.
Inhibits antigen-induced bronchospasm and histamine release from mast cells. Efficacy is indicated by reduction of the following:
nasal congestion and sneezing; watery or red eyes; itching nose, palate, or eyes.
Relief of symptoms associated with seasonal allergic rhinitis, and chronic urticaria.
Hypersensitivity to fexofenadine or terfenadine; neonates; pregnancy (category C).
Mild to severe renal and hepatic insufficiency, hypertension, diabetes mellitus, ischemic heart disease, increased ocular
pressure, hyperthyroidism, renal impairment, or prostatic hypertrophy; young children.
Route & Dosage
Adult/Child (>12 y): PO 60 mg b.i.d. OR 180 mg q.d.
Child (611 y): PO 30 mg b.i.d.
Adult: PO 60 mg b.i.d. OR 180 mg q.d.
Child (211 y): PO 30 mg b.i.d.
Infant (>6 mo): PO 15 mg b.i.d.
Clcr <80 mL/min: reduce to one dose per day
- Reduce starting dose for those with decreased kidney function.
- Do not give within 15 min of an aluminum- or magnesium-containing antacid.
- Store at 20°25° C (68°77° F). Protect from excess moisture.
Adverse Effects (≥1%)CNS: Headache,
Nausea, dyspepsia, throat irritation.
will decrease serum level of fexofenadine. Herbal: St. John's wort
will decrease serum level of fexofenadine. Food: Grapefruit juice
may decrease efficacy.
Rapidly from GI tract, 33% reaches systemic circulation. Onset:
1 h. Peak:
23 h. Duration:
At least 12 h. Distribution:
6070% bound to plasma proteins. Metabolism:
Only 5% of dose metabolized in liver. Elimination:
80% in urine, 11% in feces. Half-Life:
Assessment & Drug Effects
- Monitor therapeutic effectiveness, which is indicated by decreased nasal congestion, sneezing, watery or red eyes, and itching
nose, palate, or eyes.
Patient & Family Education
- Note: Drug is well tolerated and causes minimal adverse effects.