ETHOSUXIMIDE AND PHENOBARBITAL

Primidone lowers serum ethosuximide levels and possibly shortens its half-life. Similarly, phenobarbital has been reported both to reduce and not affect the half-life of ethosuximide. Phenobarbital levels (from primidone) do not appear to be affected by ethosuximide.
The clinical significance of these effects is unclear.
(14)
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