Studies suggest that no important interaction occurs between
entacapone and imipramine or between
tolcapone and desipramine.
Despite these studies, the manufacturer of
entacapone says there is limited
clinical experience of the use of
entacapone with tricyclic antidepressants, and they therefore recommend caution. Similarly, the manufacturers of
tolcapone suggest that caution should be exercised if desipramine is taken concurrently.