Entacapone potentiated the increase in heart rate and arrhythmogenic effects of isoprenaline (isoproterenol) and adrenaline (
epinephrine) in a study in healthy subjects.
The manufacturers of
entacapone and
tolcapone suggest caution on the concur- rent use of drugs such as adrenaline (
epinephrine), dobutamine, dopamine, isoprenaline (isoproterenol) and noradrenaline (norepinephrine).