PREPARE: Continuous: Prepare immediately prior to use. Reconstitute 5 mg or 20 mg vials with 2.5 mL or 10 mL, respectively, of sterile water
for injection to yield approximate concentration of 2 mg/mL. Slowly add sterile water to vial, avoid inverting or shaking
vial, gently swirl until powder is completely dissolved. Slowly withdraw calculated dose from vial, add to infusion bag
of NS by directing stream to side of bag to minimize agitation, then gently invert to mix. Final concentration should be
100200 mcg/mL. Do not transport infusion bag between locations attached to mechanical pump. Note: When using a syringe
pump, solution is typically diluted to a final concentration of 1001000 mcg/mL.
ADMINISTER: Continuous: Give over 96 h. Dose adjustment based on clinical or laboratory parameters is not recommended. IV must be completed within
12 h after solution is prepared.
INCOMPATIBILITIES Solution/additive: Do not mix with any other drugs. Y-site: Amiodarone, ampicillin/sulbactam sodium, ceftazidime, ciprofloxacin, clindamycin, cyclosporine, dobutamine, dopamine, epinephrine, fosphenytoin, furosemide, gentamicin, heparin sodium, human serum albumin, imipenem/cilastatin, insulin human (regular), levofloxacin, magnesium sulfate, metronidazole, midazolam, nitroprusside sodium, norepinephrine bitartrate, piperacillin/tazobactam sodium, potassium phosphate, ranitidine, ticarcillin/clavulanate, tobramycin sulfate, vancomycin.