Classifications: eye preparation; carbonic anhydrase inhibitor; Therapeutic: carbonic anhydrase inhibitor
Pregnancy Category: C
2% ophthalmic solution
Dorzolamide is a sulfonamide and inhibits carbonic anhydrase in the eye, thus reducing the rate of aqueous humor formation
with subsequent lowering of IOP. Elevated IOP is a major risk factor in the pathogenesis of optic nerve damage and visual
field loss due to glaucoma.
Lowers IOP in glaucoma or ocular hypertension.
Elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Previous hypersensitivity to dorzolamide; pregnancy (category C).
History of hypersensitivity to other carbonic anhydrase inhibitors, sulfonamides, or thiazide diuretics; ocular infection
or inflammation; recent ocular surgery; moderate-to-severe renal or hepatic insufficiency; angle-closure glaucoma; concomitant
use of oral carbonic anhydrase inhibitors; older adults, corneal abrasion.
Route & Dosage
|Glaucoma, Ocular Hypertension
Adult/Child: Ophthalmic 1 drop in affected eye t.i.d.
- Apply gentle pressure to lacrimal sac during and immediately following drug instillation for about 1 min to lessen degree
of systemic absorption.
- Administer at least 10 min apart, if another ophthalmic drug is being used concurrently.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)CNS:
Bitter taste, nausea. Special Senses: Transient burning or stinging, transient blurred vision,
superficial punctate keratitis, tearing, dryness, photophobia, ocular
allergic reaction. Skin:
Some systemic absorption from topical instillation. Onset:
2 h. Duration:
812 h. Distribution:
Distributes into red blood cells. Elimination:
In urine. Half-Life:
RBC elimination about 4 mo.
Assessment & Drug Effects
- Inquire about previous hypersensitivity to sulfonamides prior to therapy.
- Withhold drug and notify physician if S&S of local or systemic hypersensitivity occur (see Appendix F).
- Withhold the drug and notify the physician if ocular irritation occurs.
- Lab tests: Monitor CBC, serum electrolytes, and renal and liver function tests periodically with long-term therapy.
Patient & Family Education
- Learn proper technique for applying eyedrops.
- Do not allow tip of drug dispenser to come in contact with the eye.
- Discontinue drug and report to physician: ocular irritation, infection, or S&S of systemic hypersensitivity occur (see Appendix