(DOOR nase AL fa) Brand: Pulmozyme
• Do not dilute or mix the dornase alfa solution with any another drugs in the nebulizer. Mixing of dornase alfa with another drugs could lead to changes in the actions of the medications.
• Ampules of dornase alfa do not contain a preservative. Once opened, the entire contents of the ampule should be used or discarded.
• Dornase alfa should be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong easy. Hold unused ampules in the protective foil pouch. Dornase alfa must be kept refrigerated during transport. Combined lengths of exposure of the medicine to room temperature must not exceed 24 hours.
• Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis.
• Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections.
• Dornase alfa may also be used for purposes another than those listed in this medicine guide.
• Do not use dornase alfa if you have had an allergic reaction to it or to another Chinese Hamster Ovary cell products.
• Till using dornase alfa, speak your doctor if you have any another medical conditions or if you take another prescription or over-the-counter medicines. You may require a dosage adjustment or particular monitoring during your treatment.
• Dornase alfa is in the FDA pregnancy category B. This means that it is not expected to be deleterious to an unborn child. Do not use this medicine without first talking to your doctor if you are pregnant or could become pregnant during treatment.
• It is not known whether dornase alfa passes into breast milk. Do not use dornase alfa without first talking to your doctor if you are breast-feeding a baby.
• Use dornase alfa exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
• Dornase alfa is administered by inhalation using a recommended nebulizer. Your doctor or another healthcare provider will give you detailed instructions on the use and maintenance of the nebulizer.
• Do not dilute or mix the dornase alfa solution with any another drugs in the nebulizer. Mixing of dornase alfa with another drugs could lead to changes in the actions of the medications.
• If you are also taking another respiratory medications, use them in the order directed by your doctor (e.g., a bronchodilator, followed by chest physiotherapy, then dornase alfa, etc.) Do not dilute or mix dornase alfa with another agents in the nebulizer at the same time.
• Ampules of dornase alfa do not contain a preservative. It is intended for one-time use only. Once opened, the entire contents of the ampule should be used or discarded.
• Do not use any dornase alfa solution that is cloudy or discolored. Throw away any unused dornase alfa on the expiration date stamped on the ampule.
• Dornase alfa must be used on a regular basis to get the most benefit.
• Dornase alfa should be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong easy. Hold unused ampules in the protective foil pouch. Dornase alfa must be kept refrigerated during transport. Combined lengths of exposure of the medicine to room temperature must not exceed 24 hours.
• Use the missed doze as soon as you remember. However, if it is nearly time for the following doze, skip the doze you missed and use only the following regularly scheduled doze as directed. Do not use a double dose.
• An overdose of dornase alfa is unlikely to threaten life. If an overdose is suspected, contact your doctor, a hospital abnormal room, or a poison control center.
• Symptoms of a dornase alfa overdose are not known.
• Do not dilute or mix the dornase alfa solution with any another drugs in the nebulizer. Mixing of dornase alfa with another drugs could lead to changes in the actions of the medications.
• If you experience any of the next serious side effects while taking dornase alfa, search abnormal medical attention or contact your doctor immediately:
· an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or person; or hives);
· heighten difficulty breathing;
· chest pain; or
· fever.
• Smaller serious side effects may be more likely to occur with the use of dornase alfa. Conversation to your doctor if you experience any of the next side effects:
· voice alteration;
· sore throat;
· rash;
· laryngitis;
· eye redness, irritation, or inflammation; or
· nasal stuffiness or discharge.
• Side effects another than those listed here may also occur. Conversation to your doctor about any side effect that seems unusual or that is especially bothersome. You may message side effects to FDA at 1-800-FDA-1088.
• There are no known interactions between dornase alfa and another medicines. Conversation to your doctor or pharmacist till taking any another prescription or over-the-counter medicines, including herbal commodity, during treatment with dornase alfa.
• Your pharmacist has more information about dornase alfa written for health professionals that you may read.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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