Classifications: mucolytic; Therapeutic: mucolytic
Pregnancy Category: B
1 mg/mL solution for inhalation
Dornase is a solution of recombinant human deoxyribonuclease (DNAse), an enzyme that selectively cleaves DNA. In cystic fibrosis
(CF) patients, viscous, purulent secretions in the airway reduce pulmonary function and lead to exacerbations of infection.
Purulent pulmonary secretions contain very high concentrations of DNA released by degenerating leukocytes that are present
in response to infection.
Dornase hydrolyzes the DNA in sputum of CF patients and reduces sputum viscosity. Use of dornase significantly reduces number
of upper respiratory infections acquired by patients with CF.
In combination with standard therapies to reduce the frequency of respiratory infections in patients with CF and to improve
Hypersensitivity to dornase or hamster protein; infants <3 mo.
Pregnancy (category B), lactation.
Route & Dosage
Adult/Child (>3 mo): Inhalation 2.5 mg (1 ampule) inhaled once daily using a recommended nebulizer, may increase to twice daily (do not mix with other agents in nebulizer)
- Do not dilute or mix with any other drugs or solutions in the nebulizer.
- Use only with nebulizer systems recommended by the drug manufacturer.
- Do not shake ampuls; do not use ampuls that have been at room temperature longer than 24 h or have become cloudy or discolored.
- Store refrigerated at 2°8° C (36°46° F) in protective foil pouch.
Adverse Effects (≥1%)Respiratory:
Hoarseness, sore throat
, voice alterations, pharyngitis, laryngitis, cough, rhinitis. Other: Conjunctivitis
, chest pain, rash.
Minimal systemic absorption. Onset:
38 d. Duration:
Benefit lasts up to 4 d after discontinuing treatment.
Assessment & Drug Effects
- Monitor for improvement in dyspnea and sputum clearance.
- Monitor for S&S of hypersensitivity (see Appendix F). Patients with a history of hypersensitivity to bovine pancreatic dornase
are at high risk.
- Monitor for adverse effects; rarely, dosage adjustments may be required.
Patient & Family Education
- Report rash, hives, itching, or other S&S of hypersensitivity to physician immediately.
- Know potential adverse effects and report those that are bothersome or do not disappear.
- Take a missed dose as soon as possible; if it is almost time for the next dose, skip the missed dose.