Cimetidine may reduce the clearance of pramipexole by 35%. Ciprofloxacin increases the AUC of ropinirole by 84%. The manufacturers therefore predict that other CYP1A2 inhibitors (they name cimetidine) will interact similarly.
The
clinical relevance of these interactions do not appear to have been assessed. The manufacturers recommend considering a dose reduction of the
dopamine agonist if
cimetidine is used.