DIURETICS AND PROTEASE INHIBITORS

Saquinavir increases the AUC of eplerenone 2.1-fold. The manufacturer predicts that nelfinavir and ritonavir will interact to a greater extent.
The manufacturer recommends a maximum eplerenone dose of 25 mg daily in
those taking saquinavir. Because they predict a greater effect with nelfinavir and ritonavir they contraindicate the concurrent use of these protease inhibitors.
(14)
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