DIURETICS AND POTASSIUM - SPIRONOLACTONE OR TRIAMTERENE

The concurrent use of spironolactone or triamterene with potassium supplements can result in severe and even life-threatening hyperkalaemia. Amiloride is expected to interact similarly. Potassium-containing salt substitutes can be as hazardous as potassium supplements.
Concurrent use need not be avoided but close monitoring of potassium levels, both before and during treatment is necessary.