Erythromycin increases the AUC of
eplerenone 2.9-fold. The manufacturer predicts
that
clarithromycin and
telithromycin will interact to a greater extent. Eplerenone
reduced the AUC of
erythromycin by 14%, which was not considered clinically
relevant.
The manufacturers recommend a maximum
eplerenone dose of 25 mg daily in
those taking
erythromycin. Because they predict a greater effect with clarithro-
mycin and
telithromycin they contraindicate the concurrent use of these
macrolides. Other
macrolides seem less likely to interact.