The anticoagulant effects of
warfarin are increased by
disulfiram, and in some cases
bleeding has occurred.
It seems likely that most individuals will demonstrate this interaction. If
concurrent use is thought appropriate, the effects of
warfarin should be monitored
and suitable dosage adjustments made when adding or withdrawing
disulfiram.
Care should be taken when starting
warfarin in patients already taking
disulfiram,
and consideration should be given to using a smaller loading dose.