DISULFIRAM AND PHENYTOIN

Phenytoin serum levels are markedly and rapidly increased by the concurrent use of disulfiram. Phenytoin toxicity has been seen in 2 patients.
This interaction seems to occur in most patients and develops rapidly. Recovery may take 2 to 3 weeks after the disulfiram is withdrawn. Monitor phenytoin levels carefully during concurrent use. Phenytoin dosage reductions may be needed, but it may be difficult to maintain the balance required.
(48)
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