DISULFIRAM AND ISONIAZID

In most patients the use of isoniazid with disulfiram is uneventful, but a number of patients have developed difficulties in co-ordination, changes in affect and behaviour, and drowsiness.
Concurrent use need not be avoided, but if marked changes in mental status occur, or if there is unsteady gait, the manufacturers recommend that the disulfiram should be withdrawn.