DINOPROSTONE TOPICAL

(DYE no PROS tone TOP ik al) Brand: Cervidil, Prepidil, Prostin E2

What is the most significant information I must know about dinoprostone topical?

• You must not be treated with this medicine if you are allergic to prostaglandins, or if you have active genital herpes with a vaginal lesion, placenta previa, or if your water has broken.

Be certain your doctor knows your entire pregnancy history, especially if you have ever had a C-section or major surgery on your uterus, if you have ever had a child born in a breech position, or if you have ever had a difficult labor or delivery of a previous child.

• Also speak your doctor if you have kidney or liver malady, glaucoma, a history of asthma, if you are 30 years or older, or if your pregnancy is at full term (40 weeks).

• After you have received dinoprostone topical, speak your caregivers at once if your contractions slow down or become uneven, or if you have a fever, sudden vaginal bleeding, cough, wheezing, chest tightness, trouble breathing, pale skin, or blue colored lips.

After your child is born, search abnormal medical attention if you have any signs of overweening bleeding, including weakness or fainting, unusual bruising, bloody or tarry stools, coughing up blood, sudden weakness or numbness, sudden severe headache, or sudden problems with vision, speech, or balance.

What is dinoprostone topical?

• Dinoprostone is a prostaglandin, a hormone-like stuff that is naturally produced by tissues in the body.

Dinoprostone topical is used in a pregnant woman to slackening the muscles of the cervix (opening of the uterus) in preparation for inducing labor at the end of a pregnancy.

Dinoprostone topical may be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till receiving dinoprostone topical?

• You must not be treated with this medicine if you are allergic to prostaglandins, or if you have:

· active genital herpes with a vaginal lesion;

· placenta previa (the placenta is adown the fetus in your uterus); or

· if your water has broken.

Be certain your doctor knows your entire pregnancy history, especially:

· if you have ever had a C-section or major surgery on your uterus;

· if you have ever had a child born in a breech position (not head-first); or

· if you have ever had a difficult labor or delivery of a previous child.

• To create certain you can safely use dinoprostone topical, speak your doctor if you have any of these another conditions:

· kidney disease;

· liver disease;

· glaucoma;

· a history of asthma;

· if you are 30 years or older; or

· if your pregnancy is at full term (40 weeks).

How is dinoprostone topical given?

• Dinoprostone is a gel that is placed directly onto the cervix through the vagina using a particular applicator. Your doctor, nurse, or another healthcare professional will give you this medication.

• Dinoprostone is generally given while you are lying on your back. Your doctor may use a vaginal speculum to view your cervix. This will help your doctor determine how many of this medicine to use.

• After you are given this medicine, you will need to stay lying down for at least 15 minutes unless your doctor tells you otherwise.

• If your uterus does not respond to dinoprostone within 6 hours, your doctor may apply a second dose.

• If your uterus responds to the medicine, you may begin having regular uterine contractions within a little hours. You may also be given another medications to help stimulate your uterine contractions and create them more regular.

What happens if I miss a dose?

• Since dinoprostone topical is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

• Speak your caregivers right away if you think you have received too many of this medicine.

• Overdose symptoms may include heighten contractions or more intense labor pains.

What must I avoid after receiving dinoprostone topical?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of dinoprostone topical?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Speak your caregivers at once if your contractions slow down or become uneven, or if you have:

· fever;

· sudden vaginal bleeding;

· cough, wheezing, chest tightness, trouble breathing; or

· pale skin, blue colored lips.

After your child is born, search abnormal medical attention if you have any signs of overweening bleeding, such as:

· weakness or fainting;

· unusual bleeding from your nose, mouth, vagina, or rectum;

· bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· sudden numbness or weakness, especially on one side of the body;

· sudden severe headache, confusion, problems with vision, speech, or balance;

· unusual bruising, purple or red pinpoint spots under your skin;

· bleeding from a wound, surgical incision, or vein where an IV was placed;

· any bleeding that will not stop.

• Smaller serious side effects may include:

· nausea, stomach pain;

· back pain; or

· feeling of warmth in the vaginal area.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect dinoprostone topical?

• There may be another drugs that can interact with dinoprostone topical. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about dinoprostone topical

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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