Studies have found that both
diclofenac and
etoricoxib can raise the
serum digoxin levels by about one-third. Studies suggest that
serum digoxin levels are unchanged by
ibuprofen, although some reports suggest increases of up to 60% are possible.
Although rises of this extent (especially with ibuprofen) would be expected to be
clinically significant, there appear to be no reports of an interaction in practice.
Bear this interaction in mind in patients taking both drugs, and monitor
digoxin levels if a problem is suspected.