DEXTROMETHORPHAN AND MAO-B INHIBITORS

Cases of serotonin syndrome, have been seen when dextromethorphan has been used with non-selective MAOIs. The likelihood of an interaction with MAO-B inhibitors would appear to be very small, but because of the potential severity, some caution would appear to be prudent.
The manufacturer of rasagiline contraindicates its use with dextromethorphan. Some consider that patients taking selegiline should also try to avoid dextro- methorphan.
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